Etomidate: a valuable anaesthetic for mice

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Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor.

1. The GABA modulating and GABA-mimetic actions of the general anaesthetic etomidate were examined in voltage-clamp recordings performed on Xenopus laevis oocytes induced, by cRNA injection, to express human recombinant gamma-aminobutyric acidA (GABAA) receptor subunits. 2. Currents mediated by recombinant receptors with the ternary subunit composition alpha x beta y gamma 2L (where x = 1,2,3 o...

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ژورنال

عنوان ژورنال: Laboratory Animals

سال: 1981

ISSN: 0023-6772,1758-1117

DOI: 10.1258/002367781780959099